Aponick Group Research Highlighted in Nature Chemistry

“In the Aponick group, Flavio Cardoso has been studying the preparation of a new class of biaryl ligands for asymmetric catalysis. Biaryls containing 5-membered heterocycles were hypothesized to be excellent P,N-ligands, but their preparation as a single enantiomer required new design strategies. Cardoso and Aponick, with Khalil Abboud, recently published their new approach involving ground state stabilization of the chiral conformer as a�JACS�Communication. This work was recently highlighted in�Nature Chemistry�where it is noted that ?-stacking greatly increases the configurational stability of these biaryls, which function as highly enantioselective ligands in the asymmetric A3-coupling reaction. Full details can be found at:”