Matthew Eddy

Assistant Professor University of FloridaChemistry – Chemical Biology Division
Work Phone: 352 294 1048 Website:
University of Florida Department of Chemistry Gainesville Florida 32611-7200 SFH 302C
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Biographical Info

Dr. Eddy earned his undergraduate degree in Chemistry from Oberlin College, where he carried out biophysical studies under the guidance of Professor Manish Mehta to understand mechanisms of solvent-induced mechanisms of polypeptide structural changes observed by solid state nuclear magnetic resonance (NMR) spectroscopy.

During his PhD, Dr. Eddy worked in the laboratory of Professor Robert Griffin in the Department of Chemistry at the Massachusetts Institute of Technology (MIT). There, his research focused on the development of techniques to study the structures and activities of membrane proteins in native-like environments using solid state NMR spectroscopy. In particular, Dr. Eddy used magic angle spinning (MAS) NMR to study the structure and activity of the human voltage dependent anion channel (VDAC) directly in a lipid bilayer environment that mimicked the cellular membrane.

For his postdoctoral fellowship, Dr. Eddy worked jointly in the laboratories of Professor Raymond Stevens and Nobel Laureate Kurt Wüthrich at The Scripps Research Institute. Dr. Eddy’s postdoc work developed novel methods for studying function-related dynamics of human G protein-coupled receptors (GPCRs) in solution by NMR.

Dr. Eddy came to the University of Florida in the fall of 2018. His lab studies the structures and activities of human GPCRs in contexts that closely mimic the cellular environment and also directly in cells. The focus of the lab is to apply an integrative structural biology approach to unravel the effects of the cellular environment on GPCR function in cells.

2014 NIH Ruth L. Kirschstein National Research Service Award (declined)
2014-2017 American Cancer Society Postdoctoral Research Fellowship

Categories: all faculty, chemical biology, Chemical Biology Division, organic, physical, Physical Division, research faculty