James A. DeyrupProfessor Emeritus
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Our chemistry focuses on total synthesis of biologically active molecules and the design of new synthetic methodology, including antibiotics, antitumor agents, tumor promoters, cytotoxic agents, anti-HIV and anti-leukemic compounds. The construction of these molecules uses novel synthetic intermediates such as tin ketyls, samarium ketyls and free radical cyclizations. Cycloadditions are used to form multiple rings in a single step with complete regio- and stereocontrol include carbonyl-ylide [3+2]-cycloadditions and [5+2]-cycloadditions with 3-oxidopyrylium intermediates.