Alexander J. Grenning
Natural products are prized for the potential as pharmaceutical agents. A common bottleneck toward their application in disease treatment is their limited natural abundance and/or inefficient laboratory synthesis.
The Grenning research laboratory aims to design new complexity-generating chemical reactions inspired by bioactive natural products. This strategy will provide rapid access to a variety of structurally complex bioactive molecules with high step-economy. We plan to utilize the reactions developed to prepare collections of natural product inspired molecules and gain insight into their biological activities.