Chemistry

Biographical Info

To address questions regarding structure, function, dynamics, and conformational sampling of biomolecules, our lab utilizes a suite of magnetic resonance techniques. These spectroscopic methods include site-directed spin labeling (SDSL) electron paramagnetic resonance (EPR), overhauser dynamic nuclear polarization (ODNP), and nuclear magnetic resonance (NMR). We investigate a diversity of biological systems including binding, structure, and dynamics of membrane associated proteins, conformational changes in RNA riboswitch folding pathways, dynamics of natively unstructured proteins, and conformational sampling in HIV-1 protease.