Kari Basso, PhD, Director of the Mass Spectrometry Research and Education Center (MSREC) in the Department of Chemistry, has been awarded the NIH S10 Shared Instrumentation Grant for the purchase of a Q Exactive? HF hybrid Quadrupole-Orbitrap Mass Spectrometer. The Q Exactive has a resolving power of 240,000, the highest resolution mass spectrometer ever installed in the Chemistry Department at a price tag of $950,000.
The fields of metabolomics, proteomics, and lipidomics are now recognized as playing a critical role in systems biology and are becoming the focus of the development of diagnostic tests, novel drug therapies, personalized medicine, and understanding of infectious diseases, cancer, and metabolic disorders. The new Q Exactive HF Orbitrap system will be used for measuring complex mixtures of proteins, peptides, lipids, metabolites and other biomolecules requiring ultra-high resolution tandem mass spectrometry for detection, identification, and quantitation of those complex mixtures.
This data will in turn improve the outcomes of the health related goals of the projects assembled in this proposal, examples including: understanding traumatic brain injury; understanding the ubiquitin-proteasome in the treatment of human cancers including multiple myeloma and mantle cell lymphoma; understanding drug resistance to HIV-1 protease; studying Adeno-associated virus (AAV) as a delivery vehicle or vector for gene therapy; developing biosensors, bioseparation methods, targeted drug delivery, and cancer cell treatment by combining aptamers and nanomaterials; and developing and understanding the mechanism of anthelmintics.
This instrument is currently being installed in CLB 101 and is expected to be fully operational at the beginning of the Fall 2017 semester.
For more information about the MSREC, visit https://mass-spec.chem.ufl.edu/.