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Dr. Weihong Tan, the V. T. and Louise Jackson Professor of Chemistry at the University of Florida, is our principal investigator and well recognized for work in chemical biology, molecular engineering, and bionanotechnology. Tan's group has more than 25 students, postdoctors and research scientists working on three major areas:

Molecular Engineering: synthesizing novel molecular probes for bioanalysis, biosensors, biomedical applications;

Bionanotechnology: making new tools for enhanced biomedical studies using nanotechnology and nanomaterials;

Chemical Biology: understanding the molecular foundation of diseases using molecular aptamers.

Enjoy your visit here.

 

Most Recent Publications:

 


Photon-Regulated DNA-Enzymatic Nanostructures by Molecular Assembly. Mingxu You, Ruo-Wen Wang, Xiaobing Zhang, Yan Chen, Kelong Wang, Lu Peng and Weihong Tan. ACS Nano, 2011, 5 (12), pp 10090–10095. Abstract

Engineering Polymeric Aptamers for Selective Cytotoxicity. Liu Yang, Ling Meng, Xiaobing Zhang, Yan Chen, Guizhi Zhu, Haipeng Liu, Xiangling Xiong, Kwame Sefah, and Weihong Tan. J. Am. Chem. Soc., 2011, 133 (34), pp 13380–13386. Abstract

Detection of Lysozyme Magnetic Relaxation Switches Based on Aptamer-Functionalized Superparamagnetic Nanoparticles. Suwussa Bamrungsap, Mohammed Ibrahim Shukoor, Tao Chen, Kwame Sefah and Weihong Tan. Anal. Chem. Abstract

Smart Multifunctional Nanostructure for Targeted Cancer Chemotherapy and Magnetic Resonance Imaging. Tao Chen, Mohammed Ibrahim Shukoor, Ruowen Wang, Zilong Zhao, Quan Yuan, Suwussa Bamrungsap, Xiangling Xiong and Weihong Tan. ACS Nano. Abstract

Using silver nanowire antennas to enhance the conversion efficiency of photoresponsive DNA nanomotors. Quan Yuan, Yunfei Zhang, Yan Chen, Ruowen Wang, Chaoling Du, Emir Yasun, and Weihong Tan. PNAS June 7, 2011 vol. 108 no. 23 9331-9336. Abstract

Caged molecular beacons: controlling nucleic acid hybridization with light. Chunming Wang, Zhi Zhu, Yanling Song, Hui Lin, Chaoyong James Yang and Weihong Tan. Chem. Commun., 2011, 47, 5708-5710. Abstract

Molecular engineering of photoresponsive three-dimensional DNA nanostructures. Da Han, Jin Huang, Zhi Zhu, Quan Yuan, Mingxu You, Yan Chen and Weihong Tan. Chem. Commun., 2011, 47, 4670-4672. Abstract

Magnetically Driven Single DNA Nanomotor. Suwussa Bamrungsap, Joseph A. Phillips, Xiangling Xiong, Youngmi Kim, Hui Wang, Haipeng Liu, Arthur Hebard, Weihong Tan. small 2011, 7, No. 5, 601–605. Abstract

Self-Assembly of a Bifunctional DNA Carrier for Drug Delivery. Dr. Kelong Wang, Mingxu You, Dr. Yan Chen, Da Han, Zhi Zhu, Jin Huang, Dr. Kathryn Williams, Prof. Chaoyong James Yang, Prof. Dr. Weihong Tan. Angew. Chem. Int. Ed. 2011, 50, 1-5. Abstract

Aptamer-Conjugated Nanoparticles for Cancer Cell Detection. Colin D. Medley, Suwussa Bamrungsap, Weihong Tan, and Joshua E. Smith. Anal. Chem., Article ASAP. Abstract

Near-Infrared Light-Responsive Core–Shell Nanogels for Targeted Drug Delivery. Huaizhi Kang, Anna Carolina Trondoli, Guizhi Zhu, Yan Chen, Ya-Jen Chang, Haipeng Liu, Yu-Fen Huang, Xiaoling Zhang, and Weihong Tan. ACS Nano, 2011, 5 (6), pp 5094–5099. Abstract

Photoresponsive DNA-Cross-Linked Hydrogels for Controllable Release and Cancer Therapy. Huaizhi Kang, Haipeng Liu, Xiaoling Zhang, Jilin Yan, Zhi Zhu, Lu Peng, Huanghao Yang, Youngmi Kim, and Weihong Tan. Langmuir, 2011, 27 (1), pp 399¨C408. Abstract

Pyrene-Excimer Probes Based on the Hybridization Chain Reaction for the Detection of Nucleic Acids in Complex Biological Fluids. Jin Huang, Dr. Yanrong Wu, Dr. Yan Chen, Zhi Zhu, Prof. Xiaohai Yang, Prof. Chaoyong James Yang, Prof. Kemin Wang, Prof. Weihong Tan. Angewandte Chemie International Edition (Early View). Abstract

Pyrene-Assisted Efficient Photolysis of Disulfide Bonds in DNA-Based Molecular Engineering. Mingxu You, Zhi Zhu, Haipeng Liu, Basri Gulbakan, Da Han, Ruowen Wang, Kathryn R. Williams, and Weihong Tan. ACS Appl. Mater. Interfaces, Article ASAP. Abstract

A Surface Energy Transfer Nanoruler for Measuring Binding Site Distances on Live Cell Surfaces. Yan Chen, Meghan B. O¡¯Donoghue, Yu-Fen Huang, Huaizhi Kang, Joseph A. Phillips, Xiaolan Chen, M.-Carmen Estevez, Chaoyong J. Yang, and Weihong Tan. J. Am. Chem. Soc., 2010, 132 (46), pp 16559-16570. Abstract

A Dual Platform for Selective Analyte Enrichment and Ionization in Mass Spectrometry Using Aptamer-Conjugated Graphene Oxide. Basri Gulbakan, Emir Yasun, M. Ibrahim Shukoor, Zhi Zhu, Mingxu You, Xiaohong Tan, Hernan Sanchez, David H. Powell, Hongjie Dai, and Weihong Tan. J. Am. Chem. Soc. Article ASAP. Abstract

Competition-Mediated Pyrene-Switching Aptasensor: Probing Lysozyme in Human Serum with a Monomer-Excimer Fluorescence Switch. Jin Huang, Zhi Zhu, Suwussa Bamrungsap, Guizhi Zhu, Mingxu You, Xiaoxiao He, Kemin Wang, and Weihong Tan. Analytical Chemistry. Abstract

An Aptamer Cross-Linked Hydrogel as a Colorimetric Platform for Visual Detection. Zhi Zhu, Cuichen Wu, Haipeng Liu, Yuan Zou, Xiaoling Zhang, Prof., Huaizhi Kang, Chaoyong James Yang, Prof. Dr., Weihong Tan, Prof. Dr. Angew. Chem. Int. Ed. 2010, 49, 1052 –1056.   Abstract.

DNA aptamer–micelle as an efficient detection/delivery vehicle toward cancer cells.Yanrong Wu, Kwame Sefah, Haipeng Liu, Ruowen Wang, and Weihong Tan.PNAS January 5, 2010 vol. 107 no. 1 5-10. Abstract.

Engineering Dendritic Aptamer Assemblies as Superior Inhibitors of Protein Function. Youngmi Kim, Donn M. Dennis, Dr., Tim Morey, Liu Yang, Weihong Tan, Prof. Chem. Asian J. 2010, 5, 56–59. Abstract.

Single-walled carbon nanotube as an effective quencher. Zhi Zhu, Ronghua Yang, Mingxu You, Xiaoling Zhang, Yanrong Wu and Weihong Tan. Anal Bioanal Chem (2010) 396:73–83. Abstract.

Synthesis of CdS–Au2S–Au hybrid dendritic nanostructures. Shutang Chen, Xiaoling Zhang, Xiaomiao Hou, Qi Zhou and Weihong Tan. Materials Letters 64 (2010) 489–492. Abstract.

A liposome-based nanostructure for aptamer directed delivery. Huaizhi Kang, Meghan B. ODonoghue, Haipeng Liu and Weihong Tan. Chem. Commun., 2010, 46, 249 - 251. Abstract.

 

 

 

 

Group Links:

Recent Recognition of our Work (More News):

Lights on for drug delivery: "Photoresponsive DNA-Cross-Linked Hydrogels for Controllable Release and Cancer Therapy." is among he most viewed papers in material science.

Congratulations to Hui Wang and Zhi Zhu for winning Chinese Government Award for Outstanding Student Abroad.

Congratulations to Hui Wang for winning 2009 Crow-Stasch Award for excellence in a scientific
publication.

Congratulations to Yan Chen for winning Chinese Government Award for Outstanding Student Abroad.

Congratulations to Tao Chen for winning 2010 Eastman Fellowship .

In February 2010, ‘Biochemically functionalized silica nanoparticles’, was amongst the top ten accessed on the web from the online version of Analyst. (full list of top 10 articles)

"DNA aptamer/micelle as an efficient detection/delivery vehicle toward cancer cells" is one of the 30 most-read papers online during the month of January 2010 on the web of PNAS.

Congratulations to Yan Chen for being selected as a finalist in the 2010 Association for Academic Women Madelyn Lockhart Dissertation Fellowship competition.

Research news about "New nanoparticle could improve cancer detection, drug delivery."

Tan Lab had four Proctol & Gamble Research Award winners in 2009: Huaizhi Kang, Yan Chen, Kwame Sefah, and Yanrong Wu. This award is a departmental one for overall research excellence.

Congratulations to Kwame Sefah for winning the 2009-2010 Ruegamer Award for Biochemistry!

Judy Zhi Zhu won a coveted ACS Graduate Student Fellowship for 2009, which covers 9 months of work. There are only three fellowships awarded nationally each year.

Congratulations to Dalia Colon Lopez for recieving an Institutional T32 Cancer Training Grant to fund her graduate work for the next two years from the National Cancer Institute. Dr. Joe Phillips also recieved one this year.

Wired Science reports on our work in the article "Glowing DNA that Sticks to Cancer Cells."

Youngmi Kim won the 2008 Herbert A. and Marjorie G. Laitinen Graduate Fellowship for the third year in a row. This award is given to the best overall graduate students in their graduate studies.

Dr. Weihong Tan was named the V. T. and Louis Jackson Professor of Chemistry.


Last Updated on Tuesday, May 26th, 2009. Site maintained by Meghan B. O'Donoghue
The Tan Group. Chemistry Department, University of Florida.