Dr. Weihong Tan, the V. T. and Louise Jackson Professor of Chemistry at the University of Florida, is our principal investigator and well recognized for work in chemical biology, molecular engineering, and bionanotechnology. Tan's group has more than 25 students, postdoctors and research scientists working on three major areas:

Molecular Engineering: synthesizing novel molecular probes for bioanalysis, biosensors, biomedical applications;

Bionanotechnology: making new tools for enhanced biomedical studies using nanotechnology and nanomaterials;

Chemical Biology: understanding the molecular foundation of diseases using molecular aptamers.

Enjoy your visit here.

Most Recent Publications in 2009&2010:

An Aptamer Cross-Linked Hydrogel as a Colorimetric Platform for Visual Detection. Zhi Zhu, Cuichen Wu, Haipeng Liu, Yuan Zou, Xiaoling Zhang, Prof., Huaizhi Kang, Chaoyong James Yang, Prof. Dr., Weihong Tan, Prof. Dr. Angew. Chem. Int. Ed. 2010, 49, 1052 –1056.   Abstract.

DNA aptamer–micelle as an efficient detection/delivery vehicle toward cancer cells.Yanrong Wu, Kwame Sefah, Haipeng Liu, Ruowen Wang, and Weihong Tan.PNAS January 5, 2010 vol. 107 no. 1 5-10. Abstract.

Engineering Dendritic Aptamer Assemblies as Superior Inhibitors of Protein Function. Youngmi Kim, Donn M. Dennis, Dr., Tim Morey, Liu Yang, Weihong Tan, Prof. Chem. Asian J. 2010, 5, 56–59. Abstract.

Single-walled carbon nanotube as an effective quencher. Zhi Zhu, Ronghua Yang, Mingxu You, Xiaoling Zhang, Yanrong Wu and Weihong Tan. Anal Bioanal Chem (2010) 396:73–83. Abstract.

Synthesis of CdS–Au2S–Au hybrid dendritic nanostructures. Shutang Chen, Xiaoling Zhang, Xiaomiao Hou, Qi Zhou and Weihong Tan. Materials Letters 64 (2010) 489–492. Abstract.

A liposome-based nanostructure for aptamer directed delivery. Huaizhi Kang, Meghan B. ODonoghue, Haipeng Liu and Weihong Tan. Chem. Commun., 2010, 46, 249 - 251. Abstract.

Single-DNA Molecule Nanomotor Regulated by Photons. Huaizhi Kang, Haipeng Liu, Joseph A. Phillips, Zehui Cao, Youngmi Kim, Yan Chen, Zunyi Yang, Jianwei Li and Weihong Tan. Nano Lett., 2009, 9 (7), pp 2690–2696. Abstract.

Aptamers Generated from Cell-SELEX for Molecular Medicine: A Chemical Biology Approach. Xiaohong Fang and Weihong Tan. ACCOUNTS OF CHEMICAL RESEARCH. Abstract.

Using photons to manipulate enzyme inhibition by an azobenzene-modified nucleic acid probe. Youngmi Kim, Joseph A. Phillips, Haipeng Liu, Huaizhi Kang, and Weihong Tan. Proc Natl Acad Sci U S A. 106(16):6489–6494 (2009). Abstract.

Using aptamers evolved from cell-SELEX to engineer a molecular delivery platform. Mallikaratchy P, Liu H, Huang YF, Wang H, Lopez-Colon D, Tan W. Chem Commun (Camb). 7;(21):3056-8 (2009). Abstract.

Group Links:

• Instrument Reservation & Inventory

• Group Meeting Schedule (Spring 2010)

• TanLab Blog (How To Post)

• Pictures from Lab Events

Tan Lab had four Proctol & Gamble Research Award winners in 2009: Huaizhi Kang, Yan Chen, Kwame Sefah, and Yanrong Wu. This award is a departmental one for overall research excellence.