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Rachelle R. Landgrafrland@chem.ufl.edu
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About Me:
I grew up in the small town of Austwell, Texas where I graduated from Austwell-Tivoli High School with nine other people. I moved to Corpus Christi and received my Bachelor's Degree in Chemistry from Texas A&M University-Corpus Christi in 2004. I began my graduate career at the University of Florida in the fall of 2004 where I joined the Yost group and found my love for mass spectrometry.
Research Interests:
As an undergraduate, I worked under the advisement of Eugene and Feri Billiot synthesizing chiral surfactants for the separation of chiral drug compounds as well as characterizing endocrine disrupting compounds (EDCs) in environmental samples using GC-MS. I began my graduate research in collaboration with fellow Yosties, John Bowden and Chris Hilton, employing High-Field Asymmetric-Waveform Ion Mobility Spectrometry (FAIMS) to the analysis of steroids, proteins, and EDCs. After FAIMS, I began working with a new instrument, ThermoFinnigan LTQ with intermediate pressure MALDI, capable of producing mass spectral images by means of a laser microprobe. Currently, my project involves analyzing the changes in lipid content of nerve tissue caused by the administration of dichloroacetate.
Research Collaborators:
Dr. Peter W. Stacpoole, Department of Medicine, University of Florida, Gainesville, FL
Dr. Timothy J. Garrett, Department of Medicine, University of Florida, Gainesville, FL
Dr. Nigel A. Calcutt, Department of Pathology, University of California-San Diego, LaJolla, CA
Poster Presentations:
Identifying Lipid Changes in Nerve Tissue as a Result of Dichloroacetate Treatment using IP-MALDI Coupled to a Linear Ion Trap The Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics; June 3 - 7, 2007, Indianapolis, Indiana Small Molecule Analysis Session
Identifying Lipid Changes in Nerve Tissue as a Result of Dichloroacetate Treatment using Laser Desorption Mass Spectrometric Imaging 1st Annual Moffit Symposium on Mass Spectrometry; April 12, 2007, Tampa, Florida
Identifying Lipid Changes in Spinal Cord as a Result of Dichloroacetate Treatment using Laser Desorption Mass Spectrometric Imaging University of Florida College of Medicine Research Day; March 20, 2007, Gainesville, Florida
Identifying Lipid Changes in Spinal Cord as a Result of Dichloroacteate Treatment using Intermediate Pressure-MALDI Coupled to a Linear Ion Trap The Proceedings of the 18th ASMS Sanibel Conference on Imaging Mass Spectrometry; January 19 - 22, 2007, Sanibel, Florida
Effect of Carrier Gas Composition in FAIMS/MS on Separation of Charge States and Conformers of Intact Proteins The Proceedings of the 54th ASMS Conference on Mass Spectrometry and Allied Topics; May 28 - June 1, 2006, Seattle, Washington Ion Mobility Session
Oral Presentations:
Effect of Carrier Gas Composition on the Separation of Charge States and Conformers of Intact Proteins by Electrospray Ionization High-Field Asymmetric-Waveform Ion Mobility Spectrometry-Mass Spectrometry 82nd Annual Florida Meeting and Exposition of the American Chemical Society; May 11-13, 2006, Orlando, Florida Analytical Chemistry Session
Publications:
Landgraf, R.R.; Garrett, T.J.; Calcutt, N.A.; Stacpoole, P.W.; Yost, R.A. "MALDI-Linear Ion Trap Microprobe MS/MS Studies of the Effects of Dichloroacetate on Lipid Content of Nerve Tissue." Anal. Chem. 2007, in press.