Total Synthesis, New Synthetic Methodology, Synthesis of Molecules of Established Medical and Biological Activity, Free Radicals, Samarium Diodide, Ketyl Radical Anions, Cycloadditions

Our chemistry focuses on total synthesis of biologically active molecules and the design of new synthetic methodology, including antibiotics, antitumor agents, tumor promoters, cytotoxic agents, anti-HIV and anti-leukemic compounds. The construction of these molecules uses novel synthetic intermediates such as tin ketyls, samarium ketyls and free radical cyclizations. Cycloadditions are used to form multiple rings in a single step with complete regio- and stereocontrol include carbonyl-ylide [3+2]-cycloadditions and [5+2]-cycloadditions with 3-oxidopyrylium intermediates.